1345665-10-2Relevant academic research and scientific papers
Structure of cyclic nucleoside phosphonate ester prodrugs: An inquiry
Krylov, Ivan S.,Zakharova, Valeria M.,Serpi, Michaela,Haiges, Ralf,Kashemirov, Boris A.,McKenna, Charles E.
experimental part, p. 684 - 689 (2012/03/26)
The configuration at phosphorus in cyclic (S)-HPMPC (1, cidofovir) and (S)-HPMPA (2) phenyl ester (5 and 6, respectively) diastereomers ((R p)-5, (Rp)-6, (Sp)-6) was determined by X-ray crystallography and correlated to th
TYROSINE-BASED PRODRUGS OF ANTIVIRAL AGENTS
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Page/Page column 12-13, (2011/11/06)
A tyrosine-based (phosphonylmethoxyalkyl)purine or -pyrimidine conjugate is provided. In some embodiments, the conjugate includes tyrosine based amino acid or dipeptide moieties of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine or its cytosine analogue. A method of synthesizing such conjugates based on Boc-protected amino acid or dipeptides is also provided. In addition, a method of isomerizing an (S,S)-diastereoisomer to an (S,R)-diastereoisomer of an amino acid-based or dipeptide-based conjugate by a process including transesterification is provided. A method of inhibiting viral infection and a method of treating viral infection based on (phosphonylmethoxyalkyl)purine or -pyrimidine conjugates is also provided.
