1345690-14-3

Upstream product

• 1214876-54-6 (7-(chlorosulfonyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate 
• 1214876-55-7 1-(bromomethyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonyl chloride 
• 1214876-53-5 1-(1-(bromomethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone 
• 1214876-59-1 1-(bromomethyl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 1214876-52-4 (3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)-methyl methanesulfonate 
• 1214876-58-0 1-(bromomethyl)-N-(2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide 
• 1214876-56-8 1-(bromomethyl)-5-nitro-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonyl chloride 
• 885226-91-5 1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone 

Downstream Products

• 1345690-09-6 (E)-1-(bromomethyl)-N-(2-hydroxyethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide 

Relevant academic research and scientific papers

The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy

Nitro seco analogs (nitroCBIs) of the antitumor antibiotic duocarmycins are a new class of hypoxia activated prodrugs. These compounds undergo hypoxia-selective metabolism to form potent DNA alkylating agents. A series of four nitroCBI alcohol prodrugs co