1345698-93-2Relevant academic research and scientific papers
A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition
Donohue, Sean R.,Halldin, Christer,Pike, Victor W.
, p. 2789 - 2791 (2008)
Rimonabant is a high-potency cannabinoid type-1 (CB1) receptor inverse agonist that has recently been approved in the European Union as a treatment for obesity. Current methods of synthesis require several steps that have long reaction times and/or lack regioselectivity. Here we present a novel, regioselective synthesis of rimonabant though an enamine-directed 1,3-dipolar cycloaddition. In addition, we present a new and more reactive hydrazonoyl halide for the generation of the requisite nitrile imine dipole.
