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Upstream product

• 246144-90-1 (4R,5S)-3-((S)-2-allylhexanoyl)-4-methyl-5-phenyloxazolidin-2-one 
• 353291-30-2 (S)-2-allylhexanoic acid 
• 131636-15-2 (4R,5S)-3-hexanoyl-4-methyl-5-phenyloxazolidin-2-one 
• 142-61-0 Hexanoyl chloride 
• 1345706-32-2 C₃₅H₅₇F₂N₃O₆Si 
• 1345707-44-9 C₃₂H₄₆F₂N₂O₆Si 
• 1345707-42-7 C₃₉H₄₉F₂N₃O₉Si 
• 910447-68-6 (2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)pyrrolidine-1-carboxylate 
• 877078-47-2 (2R,4R)-tert-butyl 4-(allyloxy)-2-formylpyrrolidine-1-carboxylate 
• 877078-70-1 (S)-methyl 2-((S)-3-butyl-2-oxopyrrolidin-1-yl)propanoate 
• 877078-69-8 (S)-methyl 2-((S)-2-allylhexanamido)propanoate 
• 1345707-48-3 C₂₄H₄₀F₂N₂O₄Si 
• 910447-90-4 (2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)-4-hydroxypyrrolidine-1-carboxylate 
• 877078-49-4 (S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

The synthesis, evaluation, and structure-activity relationships of a class of γ-lactam 1,3-diaminopropan-2-ol transition-state isostere inhibitors of BACE are discussed. Two strategies for optimizing lead compound 1a are presented. Reducing the overall size of the inhibitors resulted in the identification of γ-lactam 1i, whereas the introduction of conformational constraint on the prime-side of the inhibitor generated compounds such as the 3-hydroxypyrrolidine inhibitor 28n. The full in vivo profile of 1i in rats and 28n in Tg 2576 mice is presented.