1345731-58-9

Basic information

• Product Name: (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine
• Synonyms: (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine
• CAS NO: 1345731-58-9
• Molecular Weight: 383.798
• Mol File: 1345731-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine(1345731-58-9)
• EPA Substance Registry System: (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine(1345731-58-9)

Safety Data

• Hazardous Substances Data: 1345731-58-9(Hazardous Substances Data)

Upstream product

• 67589-15-5 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one 
• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 402-45-9 4-hydroxybenzotrifluoride 
• 1345731-88-5 (3R,5S)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine 
• 122-01-0 4-chloro-benzoyl chloride 
• 1345731-87-4 (R)-3,5-dimethyl-7-(trifluoromethyl)-2,3-dihydro-1,4-benzoxazepine 
• 1345731-86-3 tert-butyl {(R)-2-[2-acetyl-4-(trifluoromethyl)phenoxy]-1-methylethyl}carbamate 
• 503464-99-1 1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one 

Relevant articles and documents

Discovery of potent selective orally active benzoxazepine-based orexin-2 receptor antagonists

During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett rp and Hansch-Fu