134575-38-5

Usage

Uses

Used in Pharmaceutical Industry:
(1R,5S,6s)-3-benzyl 6-ethyl 3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate is used as a pharmaceutical compound for its potential medicinal applications. Its unique structure and functional groups make it a candidate for drug development, particularly in the context of its interactions with biological targets and its potential therapeutic effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (1R,5S,6s)-3-benzyl 6-ethyl 3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate serves as a valuable molecule for research. Its structural features, which are common in drugs and bioactive molecules, allow scientists to study its properties and optimize its potential as a lead compound for the development of new medications.

Upstream product

• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 501-53-1 benzyl chloroformate 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 681851-51-4 [(1α,5α,6β)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester 
• 681851-50-3 [endo-(1R,5S)-3-(2,6-difluoro-4-nitro-phenyl)-3-aza-bicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester 
• 681851-52-5 [(1R,5S,6R)-3-(4-Amino-2,6-difluoro-phenyl)-3-aza-bicyclo[3.1.0]hex-6-yl]-carbamic acid tert-butyl ester 
• 134575-39-6 (1α,5α,6β)-6-tert-butoxycarbonylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 134677-60-4 [1α,5α,6β]-6-(tert-Butoxycarbonylamino)-3-azabicyclo[3.1.0]hexane 
• 134677-59-1 [1α,5α,6β]-3-Benzyloxycarbonyl-3-azabicyclo[3.1.0] hexane-6-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and diacylglycerol acyltransferase-1 inhibition of azabicyclo[3.1.0]hexane derivatives

We identified azabicyclo[3.1.0]hexane derivatives that are active diacylglycerol acyltransferase-1 (DGAT)-1 inhibitor. Among the azabicyclo[3.1.0]hexane series, compound 6b showed good in vitro activity toward human DGAT-1, selectivity toward DGAT-2, and

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF

(I) Disclosed herein are compounds of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt or solvate thereof; and therapeutic uses of these compounds, which are inhibitors of rearranged during transfection (RET), potentially useful in the treatment of RET-associated diseases, such as RET-associated cancers.

DEUTERATED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IMAGING AGENTS

The present invention relates to deuterated and optionally detectably labeled compounds of formula (I): R1-A-R2 and formula (V) and salts thereof, wherein Rl, R2, A, and X10-X19 have any of

6-(3-AZA-BICYCLO[3.1.0]HEX-3-YL)-2-PHENYL-PYRIMIDINES

The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has become an

Azabicyclo quinolone carboxylic acids

Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity., Antibacterial wherein, R1 is hydrogen, a pharmaceutically acceptable cation, or alkyl;, Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl;, W is hydrogen, F, Cl, Br, alkyl, alkoxy, NH2, NHCH3;, A is CH, CF, CCl, COCH3, C-CH3, C-CN or N; or, A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and, R2 is wherein R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH3, CH2NH2, CH2NHCH3 or CH2NHC2H5, and R5, R6, R7, and R9 may also independently be NH2, NHCH3 or NHC2H5.