1345822-13-0

Basic information

• Product Name: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide
• Synonyms: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide
• CAS NO: 1345822-13-0
• Molecular Weight: 429.564
• Mol File: 1345822-13-0.mol

Chemical Properties

• CAS DataBase Reference: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide(1345822-13-0)
• EPA Substance Registry System: N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-methylbenzenesulfonamide(1345822-13-0)

Safety Data

• Hazardous Substances Data: 1345822-13-0(Hazardous Substances Data)

Upstream product

• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 1345822-06-1 C₁₄H₁₇N₃OS 
• 98-59-9 p-toluenesulfonyl chloride 
• 1345822-04-9 C₁₉H₂₅N₃O₃S 

Relevant articles and documents

Antibacterial activity of thioetherhydroxyethylsulfonamide derivatives

Thioetherhydroxyethylsulfonamide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923). Results have shown tha

Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3

A series of novel thioetherhydroxyethylsulfonamide derivatives has been synthesized from the coupling of intermediates 3-amino-4-phenyl-1- thioetherazine-butan-2-oles 6,7 with arenesulfonyl chlorides in good yields. Characterizations of products were achieved by NMR techniques and specifically for compound 8e by X-ray crystallography. Preliminary results of antimalarial activity in vitro against the Plasmodium falciparum W2 clone (chloroquine resistant and mefloquine sensitive) showed moderate activity for hydroxyethylsulfonamide 8f. In addition, none of the compounds tested showed cytotoxicity at high concentration tested against HepG2 and BGM cell lines.