1345824-25-0

Basic information

• Product Name: (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide)
• Synonyms: (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide)
• CAS NO: 1345824-25-0
• Molecular Weight: 545.45
• Mol File: 1345824-25-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide)(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide)(1345824-25-0)
• EPA Substance Registry System: (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide)(1345824-25-0)

Safety Data

• Hazardous Substances Data: 1345824-25-0(Hazardous Substances Data)

Upstream product

• 5347-82-0 dimesylamine 
• 627463-17-6 4-bromo-2-fluoro-1-vinylbenzene 

Relevant articles and documents

Catalytic Asymmetric Diamination of Styrenes

An enantioselective catalytic vicinal diamination of styrenes is reported, which proceeds under entirely intermolecular reaction control. It relies on a chirally modified aryliodine(I) catalyst and proceeds within an iodine(I/III) manifold with conventional 3-chloroperbenzoic acid as a terminal oxidant. An environmentally benign solvent combination not only adds to the attractiveness of the process but also slows down the rate of the undesired background reaction. A total of 30 examples are presented, which consistently provide high enantiomeric excesses in the range 91-98%.

NOVEL IODINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS AMINATION AGENTS

The iodine compounds of the present invention corresponds to those of formula (I), wherein R1, R1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, especially metal catalysts, and confer to the amination reaction the further advantage of being performed under mild conditions, which is of interest for industrial-scale production of nitrogenated compounds with pharmaceutical, biological or medicinal applications. Therefore, the iodine compounds of the invention are useful as amination agents. The invention also discloses several processes for the preparation of the iodine compounds of formula (I).

Enantioselective metal-free diamination of styrenes

Metal-free and asymmetric: The first enantioselective diamination of styrenes simply requires a chiral hypervalent iodine(III) reagent as an oxidant and bismesylimide as a nitrogen source (see scheme, Ms=methanesulfonyl). The reaction proceeds under mild conditions and with high enantiomeric excess.