627463-17-6

Basic information

• Product Name: 4-BROMO-2-FLUORO-1-VINYLBENZENE
• Synonyms: 4-BROMO-2-FLUORO-1-VINYLBENZENE;4-Bromo-2-fluorostyrene;4-Bromo-2-fluoro-1-vinylbenzene, 4-Bromo-1-ethenyl-2-fluorobenzene;UTDQHQCPWHTKLM-UHFFFAOYSA-N
• CAS NO: 627463-17-6
• Molecular Formula: C₈H₆BrF
• Molecular Weight: 201.04
• Mol File: 627463-17-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BROMO-2-FLUORO-1-VINYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUORO-1-VINYLBENZENE(627463-17-6)
• EPA Substance Registry System: 4-BROMO-2-FLUORO-1-VINYLBENZENE(627463-17-6)

Safety Data

• Hazardous Substances Data: 627463-17-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-fluoro-1-vinylbenzene is a chemical compound with the molecular formula C8H6BrF. It is a colorless liquid with a boiling point of 166-167°C and a density of 1.454 g/mL. 4-BROMO-2-FLUORO-1-VINYLBENZENE is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as an intermediate in the production of dyes, polymers, and other organic compounds. 4-Bromo-2-fluoro-1-vinylbenzene is considered to be a potentially hazardous chemical and should be handled with care.

Upstream product

• 3536-96-7 vinylmagnesium chloride 
• 105931-73-5 1-bromo-3-fluoro-4-iodobenzene 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 934995-82-1 C₁₂H₁₂BrFO₂ 
• 623-91-6 diethyl Fumarate 
• 141-05-9 Diethyl maleate 
• 1345824-25-0 (S)-N,N’-(1-(4-bromo-2-fluorophenyl)ethane-1,2-diyl)bis(N-(methylsulfonyl)methanesulfonamide) 
• 627463-18-7 4-bromo-1-ethyl-2-fluoro-benzene 

Relevant articles and documents

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

SUBSTITUTED PIPERIDINES

The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.

4-Oxo-1-3-Substituted Phenyl-1,4-Dihydro-1,8-Napthyridene-3-Carboxamide Phosphodiesterase-4 Inhibitor and a Method of Preparing Same

The invention is directed to a compound of the structural formula (22) (22) crystal form of structural formulae (21) and its free acid, pharmaceutical compositions comprising these compounds and methods of preparing and using these compounds.