1345854-89-8 Usage
Also Known As
AG-120
Chemical Class
Aromatic amines
Mechanism of Action
Potent inhibitor of isocitrate dehydrogenase 1 (IDH1)
Role in Cellular Metabolism
Crucial enzyme in cellular metabolism
Treatment Efficacy
Effective in the treatment of acute myeloid leukemia (AML) with IDH1 mutation
Mode of Action
Inhibits mutant form of IDH1 and promotes differentiation of leukemic cells
Clinical Trial Results
Promising results in clinical trials
Potential Therapeutic Use
Investigated as a potential targeted therapy for AML and other IDH1-mutant related cancers
Check Digit Verification of cas no
The CAS Registry Mumber 1345854-89-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,5,8,5 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1345854-89:
(9*1)+(8*3)+(7*4)+(6*5)+(5*8)+(4*5)+(3*4)+(2*8)+(1*9)=188
188 % 10 = 8
So 1345854-89-8 is a valid CAS Registry Number.
1345854-89-8Relevant articles and documents
PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES
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Page/Page column 52, (2011/11/30)
Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.
