1345879-80-2

Basic information

• Product Name: C₁₁H₁₁ClFNO₂
• Synonyms: C₁₁H₁₁ClFNO₂
• CAS NO: 1345879-80-2
• Molecular Weight: 243.665
• Mol File: 1345879-80-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₁ClFNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₁ClFNO₂(1345879-80-2)
• EPA Substance Registry System: C₁₁H₁₁ClFNO₂(1345879-80-2)

Safety Data

• Hazardous Substances Data: 1345879-80-2(Hazardous Substances Data)

Upstream product

• 495405-04-4 methyl 3-fluoro-4-(4-morpholino)benzoate 
• 369-25-5 methyl 3,4-difluorobenzoate 
• 455-86-7 3,4-Difluorobenzoic acid 

Downstream Products

• 1345879-78-8 3-fluoro-4-morpholinobenzoylazide 
• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 224323-51-7 3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate 
• 165800-03-3 linezolid 
• 224323-50-6 linezolid 
• 1345879-91-5 (S)-5-(azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolin-2-one 
• 1345879-89-1 (S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one 
• 1345879-82-4 (S)-(E,Z)-5-((4-chlorobenzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one 

Relevant articles and documents

New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities

Among the different classes of antibiotics, oxazolidinone derivatives represent important drugs, since their unique mechanism of action overcomes commonly diffused multidrug-resistant bacteria. Anyway, the structural similarity of these molecules to monoa

A convenient synthesis of the antibacterial agent linezolid

Starting with 3,4-difluorobenzoic acid (8) and (S)-epichlorohydrin (13) a convergent synthesis of linezolid (1) was developed that is attractive for large scale preparation of the drug. The synthetic strategy involves a 1+3 cycloaddition reaction between the chiral epoxide 11 (prepared from 13) and isocyanate 3 (obtained from 8) that was generated in situ by a Curtius rearrangement. The resulting Schiff base precursor of linezolid (12) crystallized from the reaction mixture and was readily converted to linezolid by an acid-catalyzed hydrolysis followed by an acetylation.

PROCESSES FOR PREPARING LINEZOLID

Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.