1345879-82-4Relevant academic research and scientific papers
Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization
Bai, Meng-Meng,Cai, Jianfeng,Cui, De-Yun,Kong, Hong-Tao,Qu, Ying-Long,Shen, Bo-Yuan,Yan, Da-chao,Yang, Yi,Zhang, En,Zhang, Xiu-Juan
supporting information, (2020/04/08)
A mild and cost-effective decarboxylation cyclization method was developed for the synthesis of chiral 5-substituted thiazolidine-2-thione derivatives from β-amino oxazolidinones. This reaction was mediated by CS2 and allowed a highly stereoselective synthesis of linezolid thiazolidine-2-thione derivatives. The chirality of the linezolid base was completely retained in the final product.
A convenient synthesis of the antibacterial agent linezolid
McCarthy, James R.
, p. 6846 - 6847 (2015/11/27)
Starting with 3,4-difluorobenzoic acid (8) and (S)-epichlorohydrin (13) a convergent synthesis of linezolid (1) was developed that is attractive for large scale preparation of the drug. The synthetic strategy involves a 1+3 cycloaddition reaction between the chiral epoxide 11 (prepared from 13) and isocyanate 3 (obtained from 8) that was generated in situ by a Curtius rearrangement. The resulting Schiff base precursor of linezolid (12) crystallized from the reaction mixture and was readily converted to linezolid by an acid-catalyzed hydrolysis followed by an acetylation.
PROCESSES FOR PREPARING LINEZOLID
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, (2011/11/13)
Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.
