1345891-24-8

Basic information

• Product Name: (Z)-N-(10β-deoxoartemisinin)-N'-(2-chloro-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamidine
• CAS NO: 1345891-24-8
• Molecular Weight: 558.041
• Mol File: 1345891-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-N-(10β-deoxoartemisinin)-N'-(2-chloro-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamidine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-(10β-deoxoartemisinin)-N'-(2-chloro-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamidine(1345891-24-8)
• EPA Substance Registry System: (Z)-N-(10β-deoxoartemisinin)-N'-(2-chloro-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamidine(1345891-24-8)

Safety Data

• Hazardous Substances Data: 1345891-24-8(Hazardous Substances Data)

Upstream product

• 71939-50-9 dihydroartemisinin 
• 1119668-65-3 10-β-azidodihydroartemisinin 
• 50528-86-4 2-chloro-5-(trifluoromethyl)phenyl isocyanate 
• 123-75-1 pyrrolidine 

Relevant articles and documents

The application of tandem aza-wittig reaction to synthesize artemisinin-guanidine hybrids and their anti-tumor activity

Three series of novel artemisinin-guanidine hybrids 4a-4f, 8a-8h and 9a-9h have been facilely synthesized via four-component reaction (aza-Wittig reaction) and evaluated for their anti-tumor activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. All of the tested compounds showed enhanced anti-tumor activities with IC50 values ranging from 0.02 μM to 12.0 μM as compared to DHA (dihydroartemisinin). Among them, artemisinin derived dimers, compounds 9b (IC50 = 0.05 μM), 9d (IC50 = 0.06 μM) and 9f (IC50 = 0.02 μM) were found to be most active against HT29 cells. An efficient method to generate three series of novel artemisinin derivates using multi-component reaction was developed. From the preliminary results we can conclude that artemisinin guanidine hybrids may be promising candidates for new anticancer agents. Copyright