1345956-71-9Relevant academic research and scientific papers
DERIVATIVES OF PYRIDO [3,2-D] PYRIMIDINE, METHODS FOR PREPARATION THEREOF AND THERAPEUTIC USES THEREOF
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Paragraph 0363, (2013/05/09)
The present invention relates to a compound of the following general formula (I): wherein: R1 is notably H, a halogen or an aryl group,R2 is notably a halogen or an aryl group,R3 is notably a halogen, or an aryl or heteroaryl group, as well as to its pharmaceutically acceptable salts, its hydrates or its polymorphic crystalline structures, its racemates, diastereoisomers or enantiomers, except the compound 1-(2,4-diaminopyrido[3,2-d]pyrimidin-7-yl)-3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one.
Regiocontroled SNAr and palladium cross-coupling reactions of 2,4,7-trichloropyrido[3,2-d]pyrimidine
Tikad, Abdellatif,Akssira, Mohamed,Massip, Stephane,Leger, Jean-Michel,Jarry, Christian,Guillaumet, Gerald,Routier, Sylvain
, p. 4523 - 4532 (2012/10/30)
An efficient and original synthesis of various 2,4,7-trisubstituted pyrido[3,2-d]pyrimidines is reported. The first access to and the chemical interest of 2,4,7-trichloropyrido[3,2-d]pyrimidine is described. Double arylations and SNAr reactions occurred selectively at the C4 and C2 positions of 2,4,7-trichloropyrido[3,2-d]pyrimidine. The reactions at the C7 position were achieved under microwave irradiation in a few minutes. A one-step synthesis of a 2,4,7-tris(aminated) derivative was achieved as a highly efficient alternative. An efficient and original synthesis of 2,4,7-trisubstituted pyrido[3,2-d]pyrimidines is reported. Arylations and S NAr reactions occurred regioselectively at the C4 and C2 positions of 2,4,7-trichloropyrido[3,2-d]pyrimidine. Reactions at the C7 position were achieved under microwave irradiation in a few minutes. A one-step synthesis of a 2,4,7-tris(aminated) derivative was achieved as an efficient alternative. Copyright
