134599-99-8Relevant academic research and scientific papers
Cascade synthesis of 2-pyridones using acrylamides and ketones
Rai, Sunil K.,Khanam, Shaziya,Khanna, Ranjana S.,Tewari, Ashish K.
, p. 44141 - 44145 (2014)
Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is
Reactions of 3-aryl-1-methyl-1,3-diketones with cyanoacetamide catalyzed by lipase from Candida cylindracea: Part II
Mijin, Dusan Z.,Misic-Vukovic, Milica M.
, p. 348 - 350 (2007/10/02)
Lipase from Candida cylindracea has been used to synthesize 4,6-(methyl, aryl-disubstituted)-3-cyano-2-pyridones (2) by condensation of 3-aryl-1-methyl-1,3-diketones (1) with cyanoacetamide in water at 40 deg C.Synthesis has been performed in an excess of
