5435-66-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-NITRO-PHENYL)-BUTANE-1,3-DIONE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex organic molecules that are vital in the development of various medications.
Used in Research Laboratories:
In research settings, 1-(3-NITRO-PHENYL)-BUTANE-1,3-DIONE serves as a reagent in chemical reactions, facilitating the synthesis of new compounds for scientific exploration and discovery.
Used in Fine Chemicals Production:
1-(3-NITRO-PHENYL)-BUTANE-1,3-DIONE is utilized as a key component in the production of fine chemicals, which are high-purity chemicals used in various applications, including the formulation of specialty products and advanced materials.

InChI:InChI=1/C10H9NO4/c1-7(12)5-10(13)8-3-2-4-9(6-8)11(14)15/h2-4,6H,5H2,1H3

Upstream product

• 108-24-7 acetic anhydride 
• 121-89-1 3-Nitroacetophenone 
• 645-00-1 m-iodonitrobenzene 
• 67-64-1 acetone 
• 7664-93-9 sulfuric acid 
• 93257-82-0 ethyl-2-(3-nitrobenzoyl)-3-oxobutanoate 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 137831-57-3 3-methyl-5-(3-nitro-phenyl)-1⁽²⁾H-pyrazole 
• 87339-08-0 1-(3-amino-phenyl)-butane-1,3-dione 
• 673494-52-5 2-[(4-methylphenyl)sulfonyl]-1-(3-nitrophenyl)-1-ethanone 
• 107504-62-1 2-(5,6-Dihydro-imidazo[2,1-b]thiazol-3-yl)-1-(3-nitro-phenyl)-ethanone; hydrobromide 
• 107504-82-5 2-[5,6-Dihydro-imidazo[2,1-b]thiazol-(3E)-ylidene]-1-(3-nitro-phenyl)-ethanone 
• 189306-96-5 5-Acetyl-2-ethyl-4-nitro-6-(3-nitro-phenyl)-2H-pyridazin-3-one 
• 189306-92-1 6-Ethyl-3-methyl-4-(3-nitro-phenyl)-6H-isoxazolo[3,4-d]pyridazin-7-one 
• 189306-89-6 3-Methyl-4-(3-nitro-phenyl)-6H-isoxazolo[3,4-d]pyridazin-7-one 
• 189306-87-4 5-Methyl-4-(3-nitro-benzoyl)-isoxazole-3-carboxylic acid ethyl ester 
• 134599-99-8 4-(m-nitrophenyl)-6-methyl-3-cyano-2-pyridone 

Relevant academic research and scientific papers

Synthesis of Highly Substituted Biaryls by the Construction of a Benzene Ring via in Situ Formed Acetals

Herein, we present an interesting method for the construction of a benzene ring using propargylic alcohols and 1,3-dicarbonyls, which involves three new C-C bond formations via cascade alkylation, formylation, annulation, and aromatization to make substituted biaryls. This one-pot Br?nsted acid-promoted protocol utilizes the unique reactivity of the acetal formed under the reaction conditions. Alkynyl methyl ketones could be employed instead of 1,3-dicarbonyls as they are converted to 1,3-dicarbonyls by hydration under the reaction conditions.

Switching of Sulfonylation Selectivity by Nature of Solvent and Temperature: The Reaction of β-Dicarbonyl Compounds with Sodium Sulfinates under the Action of Iron-Based Oxidants

Selectivity of sulfonylation of β-keto esters with sodium sulfinates under the action of iron(III) salts as oxidants can be regulated by the type of solvent used and the reaction temperature. α-Sulfonyl β-keto esters are obtained when the process is conducted in THF/H2O solution at 40 °C. The change of the solvent to iPrOH/H2O and refluxing of a reaction mixture provides α-sulfonyl esters – the products of successive sulfonylation-deacylation. When β-diketones are applied as starting materials, only α-sulfonyl ketones are formed. The reaction pathway includes sulfonylation of dicabonyl compounds under the action of Fe(III) to form α-sulfonylated dicarbonyl compounds, which are then attacked by a solvent as the nucleophile, resulting in the products of successive sulfonylation-deacylation. Participation of the solvent in the reaction pathway determines the products structure.

O -Iodoxybenzoic Acid (IBX)-Iodine Mediated One-Pot Deacylative Sulfonylation of 1,3-Dicarbonyl Compounds: A Synthesis of β-Carbonyl Sulfones

A combination of o-iodoxybenzoic acid (IBX) and a catalytic amount of iodine is found to promote a facile one-pot deacylative sulfonylation reaction of 1,3-dicarbonyl compounds with sodium sulfinates to yield β-carbonyl sulfones. The present method provides the target products bearing a wide variety of functional groups in one step and in good yields.