1346146-37-9Relevant articles and documents
BACE1 inhibitors: A head group scan on a series of amides
Woltering, Thomas J.,Wostl, Wolfgang,Hilpert, Hans,Rogers-Evans, Mark,Pinard, Emmanuel,Mayweg, Alexander,G?bel, Martin,Banner, David W.,Benz, J?rg,Travagli, Massimiliano,Pollastrini, Martina,Marconi, Guido,Gabellieri, Emanuele,Guba, Wolfgang,Mauser, Harald,Andreini, Matteo,Jacobsen, Helmut,Power, Eoin,Narquizian, Robert
, p. 4239 - 4243 (2013/07/26)
A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based assay. Determination of their basicity as well as their properties as substrates
2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS
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Page/Page column 51, (2012/01/13)
This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments fo