1346148-86-4Relevant academic research and scientific papers
Catalytic enantioselective intermolecular cycloaddition of diazodiketoester-derived carbonyl ylides with indoles using chiral dirhodium(II) carboxylates
Shimada, Naoyuki,Oohara, Tadashi,Krishnamurthi, Janagiraman,Nambu, Hisanori,Hashimoto, Shunichi
, p. 6284 - 6287 (2011)
The first example of enantioselective intermolecular cycloaddition of carbonyl ylides with indoles is described. The cycloaddition of five- and six-membered carbonyl ylides derived from diazodiketoesters with N-methylindoles under catalysis by dirhodium(II) tetrakis[N-tetrachlorophthaloyl-(S)-tert- leucinate], Rh2(S-TCPTTL)4, gave cycloadducts in high yields and with high levels of enantioselectivity (up to 99% ee) as well as excellent exo diastereoselectivity.
