1346154-54-8

Basic information

• Product Name: 5-(1-(4-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-(1-(4-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 1346154-54-8
• Molecular Weight: 320.361
• Mol File: 1346154-54-8.mol

Chemical Properties

• CAS DataBase Reference: 5-(1-(4-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-(4-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(1346154-54-8)
• EPA Substance Registry System: 5-(1-(4-fluorophenyl)cyclohexyl)-2,2-dimethyl-1,3-dioxane-4,6-dione(1346154-54-8)

Safety Data

• Hazardous Substances Data: 1346154-54-8(Hazardous Substances Data)

Upstream product

• 3709-25-9 5-Cyclohexylidene-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 1381982-59-7 1-fluoro-4-(1-methylcyclohexyl)benzene 
• 1225477-99-5 [1-(4-fluorophenyl)cyclohexyl]acetic acid 

Relevant articles and documents

Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers

Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).