134619-79-7

Basic information

• Product Name: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine
• Synonyms: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine
• CAS NO: 134619-79-7
• Molecular Weight: 409.449
• Mol File: 134619-79-7.mol

Chemical Properties

• CAS DataBase Reference: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine(134619-79-7)
• EPA Substance Registry System: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine(134619-79-7)

Safety Data

• Hazardous Substances Data: 134619-79-7(Hazardous Substances Data)

Upstream product

• 33401-74-0 ethyl (3R)-3-hydroxy-3-phenylpropionate 
• 76183-10-3 (S)-3-hydroxy-N-methyl-3-phenylpropanamide 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 402-45-9 4-hydroxybenzotrifluoride 
• 134619-77-5 (-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine 

Downstream Products

• 114247-09-5 (R)-fluoxetine hydrochloride 

Relevant articles and documents

A novel chemoenzymatic enantioselective synthesis of some clinically effective CNS drugs and related compounds

We have demonstrated in this study a novel route for the synthesis of benzothiopyran and benzothiazepin ring systems along with the synthesis of optically pure, clinically effective drugs tomoxetine, fluoxetine and thiazesim.

A new chemoenzymatic enantioselective synthesis of R-(-)-tomoxetine, (R)- and (S)-fluoxetine

A new chemoenzymatic synthesis of optically pure (R)-Tomoxetine and both the enantiomers of Fluoxetine starting from (S)-ethyl-3-hydroxy-3-phenyl propionate obtained by enzymatic methods, is described.