1346220-47-0Relevant articles and documents
Silacarboxylic acids as efficient carbon monoxide releasing molecules: Synthesis and application in palladium-catalyzed carbonylation reactions
Friis, Stig D.,Taaning, Rolf H.,Lindhardt, Anders T.,Skrydstrup, Troels
supporting information; experimental part, p. 18114 - 18117 (2012/01/04)
Silacarboxylic acids have been demonstrated to be easy to handle, air-stable carbon monoxide precursors. Different silacarboxylic acids were synthesized from the corresponding chlorosilanes and carbon dioxide, and their decarbonylation, upon treatment with an array of activators, was evaluated. The release of CO from crystalline MePh2SiCO2H proved to be highly efficient, and it was successfully applied in a selection of palladium-catalyzed carbonylative couplings using near-stoichiometric quantities of carbon monoxide precursor. Finally, the synthesis of MePh2Si 13CO2H and its application in carbonyl labeling of two bioactive compounds was demonstrated.