1346229-15-9Relevant academic research and scientific papers
Multicomponent synthesis of 4-aminophthalazin-1(2 H)-ones by palladium-catalyzed isocyanide insertion
Vlaar, Tjostil,Mampuys, Pieter,Helliwell, Madeleine,Maes, Bert U. W.,Orru, Romano V. A.,Ruijter, Eelco
, p. 6735 - 6745 (2013/07/26)
4-Aminophthalazin-1(2H)-ones (APOs) are underexplored heterocyclic compounds with promising and diverse biological activities. The classical synthesis of these compounds is tedious and does not allow the regioselective introduction of substituents. Here,
Palladium-catalyzed synthesis of 4-aminophthalazin-1(2h)-ones by isocyanide insertion
Vlaar, Tjostil,Ruijter, Eelco,Znabet, Anass,Janssen, Elwin,De Kanter, Frans J.J.,Maes, Bert U.W.,Orru, Romano V. A.
supporting information; experimental part, p. 6496 - 6499 (2012/02/04)
Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by
