1346237-65-7Relevant academic research and scientific papers
Total synthesis of (-)-funebrine via Au-catalyzed regio- and stereoselective γ-butyrolactonization of allenylsilane
Okada, Takuya,Sakaguchi, Kazuhiko,Shinada, Tetsuro,Ohfune, Yasufumi
, p. 5744 - 5746 (2011)
The stereoselective total synthesis of (-)-funebrine from 2-butyn-1-ol was described. The crucial steps in the synthesis involved the stereoselective enolate Claisen rearrangement of the (S)-α-acyloxy-α-alkynylsilane 8, the Au-catalyzed regio- and stereoselective lactonization of the allenylsilane 7, and the Paal-Knorr pyrrole condensation using an unsymmetrical 1,4-diketone 4b.
