134643-01-9

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 79-03-8 propionyl chloride 
• 134731-67-2 (R,R)-trans-4,5-diphenylimidazolidin-2-one 

Downstream Products

• 134643-04-2 (4R,5R)-3-((2R,3R)-3-hydroxy-2-methyl-3-(2-naphthyl)-1-oxopropyl)-4,5-diphenyl-1-methyl-2-imidazolidinone 
• 134643-03-1 (4R,5R)-3-((2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl)-4,5-diphenyl-1-methyl-2-imidazolidinone 
• 134643-07-5 (4R,5R)-3-((2R,3S)-3-hydroxy-2-methyl-1-oxo-4-pentenyl)-4,5-diphenyl-1-methyl-2-imidazolidinone 
• 134643-06-4 (4R,5R)-3-((2R,3S)-3-hydroxy-2-methyl-1-oxopentyl)-4,5-diphenyl-1-methyl-2-imidazolidinone 
• 134643-05-3 (4R,5R)-3-((2R,3S)-3-hydroxy-2-methyl-1-oxobutyl)-4,5-diphenyl-1-methyl-2-imidazolidinone 
• 134643-02-0 (4R,5R)-4,5-diphenyl-1-methyl-3-propionyl-2-imidazolidinone 

Relevant academic research and scientific papers

Synthesis of C2 symmetric 2,2′-bipyridyl imidazolidinone and oxazaborolidine derivatives

4,4′-Bis(bromomethyl)-2,2′-bipyridine reacts with (4R, 5R)-1-propanoyl-4,5-diphenylimidazolidinone to form a C2 symmetric chiral bipyridine derivative. Similarly reaction of 4,4′-bis(bromomethyl)-2,2′-bipyridine with an amino alcohol prepared from L-tyrosine affords a C2 symmetric diaminodiol. Treatment of the latter product with either borane or trimethylboroxine forms oxazaborolidines that have been used as catalysts in the asymmetric reduction of acetophenone. High enantiomeric excesses are obtained.

New Chiral Auxiliary; 4,5-Diphenyl-1-methyl-2-imidazolidinone. Its Utility in Highly Enantioselective Aldol Reaction

The aldol reaction of the boron enolate bearing the titled chiral auxiliary proceeded with high face selectivity.