1346434-19-2

Upstream product

• 1346434-18-1 9-(2-(N-tBOC-N-methylamino)methyl)fluorenylmethanol 
• 1346434-76-1 2-((N-tBOC-N-methylamino)methyl)-fluorene-9-carboxaldehyde 
• 1346434-17-0 2-((N-tBOC-N-methylamino)methyl)fluorene 
• 7507-40-6 9H-fluorene-2-carboxylic acid 
• 62-53-3 aniline 
• 16331-50-3 9H-fluorene-2-carbonyl chloride 

Downstream Products

• 1346434-20-5 O-(9-(2-((N-(6-azidohexanoyl)-N-methylamino)methyl)fluorenyl)methyl) N-phenylcarbamate 
• 1346434-21-6 O-(9-(2-((N-(6-azidohexanoyl)-N-methylamino)methyl)fluorenyl)methyl) N-phenyl-N-chloromethylcarbamate 
• 1346434-22-7 C₅₂H₅₁N₇O₈ 

Relevant academic research and scientific papers

CONTROLLED DRUG RELEASE FROM SOLID SUPPORTS

The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.

CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES

The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.