1346445-80-4Relevant academic research and scientific papers
Development of safe one-pot synthesis of N-1- and C-2-substituted benzimidazole via reductive cyclization of o-nitroarylamine using Na 2S2O4
Oda, Shinichi,Shimizu, Hideki,Aoyama, Yasunori,Ueki, Tatsuo,Shimizu, Sumio,Osato, Hiroshi,Takeuchi, Yoshiyuki
, p. 96 - 101 (2012)
We report that the reductive cyclization of o-nitroarylamine with aldehyde using sodium dithionite (Na2S2O4) could be accelerated by addition of H2O, which made it possible to control the heat release of the reaction by semibatch-type operation. Safety evaluation was performed using DSC, ARSST, in situ IR analysis, and Multimax.
