134650-71-8

Upstream product

• 321309-27-7 4-isothiocyanato-3,5-dimethyl-1,2-oxazole 
• 100-61-8 N-methylaniline 

Downstream Products

• 134650-85-4 1-<5-methyl-2-(N-methyl-N-phenylamino)thiazol-4-yl>ethan-1-one 
• 134650-93-4 N-(1-acetyl-2-aminoprop-1-enyl)-N'-methyl-N'-phenylthiourea 
• 134650-86-5 1-<2(benzylamino)-5-methylthiazol-4-yl>ethan-1-one 

Relevant academic research and scientific papers

Transformations in the isoxazole series: Synthesis of substituted 2-aminothiazoles

Substitued N-(isoxazol-4-yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one-pot reaction. In a few cases, 1,4,5-trisubstituted dihydroimidazoleth, iones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed.