134651-01-7

Upstream product

• 134650-77-4 1-(tert-butyl)-3-(3,5-dimethylisoxazol-4-yl)-2-methylisothiourea 
• 134650-67-2 N-(tert-butyl)-N'-(3,5-dimethylisoxazol-4-yl)thiourea 
• 321309-27-7 4-isothiocyanato-3,5-dimethyl-1,2-oxazole 

Relevant academic research and scientific papers

Transformations in the isoxazole series: Synthesis of substituted 2-aminothiazoles

Substitued N-(isoxazol-4-yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one-pot reaction. In a few cases, 1,4,5-trisubstituted dihydroimidazoleth, iones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed.