134653-95-5Relevant academic research and scientific papers
4-oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: Structural insights into the design of a novel inverse agonist series
El Bakali, Jamal,Muccioli, Giulio G.,Renault, Nicolas,Pradal, Delphine,Body-Malapel, Mathilde,Djouina, Madjid,Hamtiaux, Laurie,Andrzejak, Virginie,Desreumaux, Pierre,Chavatte, Philippe,Lambert, Didier M.,Millet, Régis
scheme or table, p. 7918 - 7931 (2011/03/19)
Growing evidence shows that CB2 receptor is an attractive therapeutic target. Starting from a series of 4-oxo-1,4-dihydroquinoline-3- carboxamide as selective CB2 agonists, we describe here the medicinal chemistry approach leading to
1,4 DIHYDROPYRIDINE DERIVATIVES AND THEIR USES
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Page/Page column 33, (2010/12/18)
The present invention relates to 1,4-dihydropyridine derivatives of the formula (I) and their uses in the treatment and/or prevention of diseases and disorders directly or indirectly associated with the modification (increase or decrease) of the activity
Generation and in Situ Acylation of Enaminone Anions: A Convenient Synthesis of 3-Carbethoxy-4(1H)-pyridinones and -4-pyrones and Related Compounds
McCombie, Stuart W.,Metz, William A.,Nazareno, Dennis,Shankar, Bandarpalle B.,Tagat, Jayaram
, p. 4963 - 4967 (2007/10/02)
Treatment of 2--3-oxobutanoates 9 or 10 with LiN(SiMe3)2 in the presence of RCOCl results in C-acylation.The resulting intermediate, without isolation, may be converted to 6-R 3-Carbethoxy-4-pyrones (e.g., 12) by H3O+ or to the corresponding pyridinones (e.g., 13) by NH4OAc.Typically, yields are 55-75percent for R groups lacking acidic α or γ protons and ca. 30percent for R = Me2CH or MeCH=CH.Replacing 9 with MeCOC(=CHNMe2)SCH2Ph (from MeCOCH2SCH2Ph and Me2NCH(OMe)2 similarly affords 3-(PhCH2S)-substituted products such as 29.Alkylation of the pyridinone anions produces mixtures of N- and O-substituted compounds, with the latter predominating; aminolysis of the isolated pyrones (R'NH2-HOAc, where R' = alkyl, Ar, HO, etc.) is the preferred route to the 1-R'-substituted pyridinones.
