1346540-41-7Relevant academic research and scientific papers
Pd/Josiphos-catalyzed enantioselective α-arylation of silyl ketene acetals and mechanistic studies on transmetalation and enantioselection
Kobayashi, Kenya,Yamamoto, Yasunori,Miyaura, Norio
, p. 6323 - 6327 (2011)
Palladium/(4-MeO-3,5-MePh)2PF-Pcy2) catalyzed the enantioselective arylation of silyl ketene acetals with iodoarenes in the presence of TlOAc to promote transmetalation of silyl ketene acetals. The highest enantioselectivities giving α-arylesters up to 91% ee were achieved when (E)-1-methoxy-1-(trimethylsiloxy)propene (E/Z = 88/12) was used for the silyl ketene acetal. The effect on enantioselection of a chiral ligand is discussed on the basis of the X-ray structure of the palladium/(4-MeO-3,5- MePh)2PF-Pcy2) complex and results of DFT computational studies on mechanistic aspects of the catalytic cycle.
