1346558-32-4Relevant academic research and scientific papers
Phenolic Bis-styrylbenzo[ c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of Aβ Plaque Heterogeneity
Zhang, Jun,Konsmo, Audun,Sandberg, Alexander,Wu, Xiongyu,Nystr?m, Sofie,Obermüller, Ulrike,Wegenast-Braun, Bettina M.,Konradsson, Peter,Lindgren, Mikael,Hammarstr?m, Per
, p. 2038 - 2048 (2019)
A fluorescent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analogue) showed lower binding affinity toward Aβ1-42 and Aβ1-40 fibrils than its neutral analogue. Hence, variable patterns of neutral OH-substituted bis-styryl-BTDs were generated. All bis-styryl-BTDs showed higher binding affinity to Aβ1-42 fibrils than to Aβ1-40 fibrils. The para-OH on the phenyl rings was beneficial for binding affinity while a meta-OH decreased the affinity. Differential staining of transgenic mouse Aβ amyloid plaque cores compared to peripheral coronas using neutral compared to anionic bis-styryl ligands indicate differential recognition of amyloid polymorphs. Hyperspectral imaging of transgenic mouse Aβ plaque stained with uncharged para-hydroxyl substituted bis-styryl-BTD implicated differences in binding site polarity of polymorphic amyloid plaque. Most properties of the corresponding bis-styryl-BTD were retained with a rigid alkyne linker rendering a probe insensitive to cis-trans isomerization. These new BTD-based ligands are promising probes for spectral imaging of different Aβ fibril polymorphs.
Linearly polarized photoluminescence from an asymmetric cyclophane showing thermo- and mechanoresponsive luminescence
Sagara, Yoshimitsu,Seki, Atsushi,Kim, Yuna,Tamaoki, Nobuyuki
, p. 8453 - 8459 (2018)
The first cyclophane to exhibit linearly polarized photoluminescence in the liquid-crystalline and crystalline states is described. An asymmetric cyclophane featuring a 4,7-bis(phenylethynyl)-2,1,3-benzothiadiazole group forms a thermodynamically metastab
Polymer-based fluorescent sensor incorporating 2,2′-bipyridyl and benzo[2,1,3]thiadiazole moieties for Cu2+ detection
Dong, Yu,Koken, Biyhaliy,Ma, Xiao,Wang, Lu,Cheng, Yixiang,Zhu, Chengjian
, p. 1719 - 1722 (2011/11/30)
The polymer was synthesized by the polymerization of 4,4′-((4- iodophenoxy)methyl)-2,2′-bipyridine (M-1) with 4,7-diethynylbenzo[2,1,3]- thiadiazole (M-2) via Pd-catalyzed Sonogashira reaction. The fluorescence responses of the polymer towards various tra
