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1346569-67-2

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1346569-67-2 Usage

General Description

1H-Pyrrolo[3,2-b]pyridine-5-methanol, also known as PPM, is a chemical compound with potential therapeutic applications. It is a heterocyclic compound with a pyrrolopyridine core, and a hydroxymethyl group attached to the fifth position of the ring. 1H-Pyrrolo[3,2-b]pyridine-5-methanol has been studied for its potential use as a medication for various diseases, including cancer and autoimmune disorders. PPM is a promising candidate for drug development due to its ability to modulate biological pathways and potentially act as a targeted therapy for specific conditions. Further research is needed to fully understand the mechanisms of action and potential side effects of this compound, but it shows promise as a therapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 1346569-67-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,5,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1346569-67:
(9*1)+(8*3)+(7*4)+(6*6)+(5*5)+(4*6)+(3*9)+(2*6)+(1*7)=192
192 % 10 = 2
So 1346569-67-2 is a valid CAS Registry Number.

1346569-67-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-pyrrolo[3,2-b]pyridin-5-ylmethanol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1346569-67-2 SDS

1346569-67-2Relevant articles and documents

Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists

Lingam, V. S. Prasadarao,Dahale, Dnyaneshwar H.,Rathi, Vijay E.,Shingote, Yogesh B.,Thakur, Rajni R.,Mindhe, Ajit S.,Kummari, Srinivas,Khairatkar-Joshi, Neelima,Bajpai, Malini,Shah, Daisy M.,Sapalya, Ratika S.,Gullapalli, Srinivas,Gupta, Praveen K.,Gudi, Girish S.,Jadhav, Satyawan B.,Pattem, Rambabu,Thomas, Abraham

supporting information, p. 8292 - 8308 (2015/11/09)

We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactive diarylpyridine-2-amine derivative 3b by extensive and systematic analogue synthesis and SAR analysis. Further optimization of the scaffold resulted in identification of pyridin-2(1H)-one 18b as a lead compound with good potency (IC50 = 1.6 nM) and selectivity (>6000-fold) over other related PDEs but with a poor pharmacokinetic profile. Careful metabolite profiling of 18b revealed that poor systemic exposure in rats (Cmax = 44 ng/mL; AUC0-t = 359 ng·h/mL) at 10 mg/kg was due to the formation of O-glucuronide conjugate by phase 2 metabolism. The structure of the glucuronide metabolite was confirmed by retention time and LC-MS/MS fragmentation matching with the synthetic glucuronide 26. The problem of low exposure of 18b was effectively addressed by its conversion to an acetate prodrug 25b, which upon oral dosing resulted in an improved pharmacokinetic profile (Cmax = 359 ng.h/mL; AUC0-t = 2436 ng.h/mL) and a desirable brain to plasma ratio of 1.2. The prodrug 25b showed good efficacy in selected rodent models of psychosis.

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