134660-34-7Relevant academic research and scientific papers
Nucleoside Analogues. Part 11. The Acylation of N-(ω-Aminoalkyl)uracil and a Bicyclic Isomer
McCormick, Joan E.,McElhinney, R. Stanley,McMurry, T. Brian H.
, p. 1216 - 1239 (2007/10/02)
The relative reactivity of the amino group and of pyrimidine N1 and N3 in N-(ω-aminoalkyl)uracils has been investigated using a variety of acylating agents.Bis(2,4,5-trichlorophenyl) carbonate, now readily available from bis(trichloromethyl) carbonate, proved a very useful selective reagent.The bicyclic isomer formed from an N1-substituted compound by intramolecular addition was also studied and afforded novel products from 2,4,5-trichlorophenyl N-(2-chloroethyl)-N-nitrosocarbamate, a standard reagent for producing N-nitrosoureas.
