16947-69-6

Usage

Chloroformate ester derivative

2,4,5-trichlorophenol It is derived from 2,4,5-trichlorophenol, which is a chloroformate ester.

Usage

Organic synthesis reagent It is commonly used in organic synthesis for the preparation of carbamates and other organic compounds.

Physical appearance

Colorless to pale yellow liquid It has a colorless to pale yellow appearance.

Odor

Pungent It has a strong, pungent odor.

Reactivity

Highly reactive It is highly reactive, making it a useful intermediate in the production of various chemicals and pharmaceuticals.

Potential hazards

Corrosive and irritant It can be corrosive and irritating to the skin, eyes, and respiratory system.

Safety precautions

Handle with care in a well-ventilated area with appropriate protective equipment Due to its potential hazards, it should be handled with care and proper safety measures, such as working in a well-ventilated area and wearing protective gear.

InChI:InChI=1/C7H2Cl4O2/c8-3-1-5(10)6(2-4(3)9)13-7(11)12/h1-2H

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 95-95-4 2,4,5-trichlorophenol 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 60450-67-1 tert.-Butyl-2,4,5-trichlorphenyl-dicarbonat 
• 57699-78-2 N-tert-Butoxycarbonyl-α-azaphenylalanin-(2,4,5-trichlor-phenyl)-ester 
• 135264-86-7 N-(2,4,5-trichlorophenoxycarbonyl)imidazole 
• 3942-57-2 2,4,5-trichlorophenyl N-methylcarbamate 
• 81420-42-0 mononitrophenyl carbonate 
• 91390-34-0 2,4,5-trichlorophenyl (2-fluoroethyl)carbamate 
• 88-75-5 2-hydroxynitrobenzene 
• 134660-34-7 [2-(5-Fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-2-methylsulfanyl-ethyl]-carbamic acid 2,4,5-trichloro-phenyl ester 
• 135264-93-6 [2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methylsulfanyl-ethyl]-carbamic acid 2,4,5-trichloro-phenyl ester 
• 135264-95-8 8-Fluoro-3-methylsulfanyl-5,7-dioxo-hexahydro-imidazo[1,2-c]pyrimidine-1-carboxylic acid 2,4,5-trichloro-phenyl ester 
• 3065-27-8 benzyloxycarbonyl-L-phenylalanine 2,4,5-trichlorophenyl ester 
• 4865-50-3 Z-glycine-OTCP 
• 65689-39-6 Carbonic acid 2,4,5-trichloro-phenyl ester 2,4,6-trimethyl-benzyl ester 
• 80354-46-7 2,4,5-trichlorophenyl N-(2-chloroethyl)carbamate 

Relevant academic research and scientific papers

A convenient method for the synthesis of activated N-methylcarbamates

An investigation of methods to efficiently prepare activated N-methylcarbamates is reported. N-(Methylcarbamoyloxy)succinimide (3a), aryl N-methylcarbamates 3b-d and 2,2,2-trifluoro-1-(trifluoromethyl)ethyl N-methylcarbamate (3e) have been prepared in 70-80% yields from the corresponding chloroformates 5a-e, which were prepared as crystalline solids by the condensation of trichloromethylchloroformate (1) or bis(trichloromethyl)carbonate (2) with hydroxy compounds 4a-e in high yields.

Nucleoside Analogues. Part 11. The Acylation of N-(ω-Aminoalkyl)uracil and a Bicyclic Isomer

The relative reactivity of the amino group and of pyrimidine N1 and N3 in N-(ω-aminoalkyl)uracils has been investigated using a variety of acylating agents.Bis(2,4,5-trichlorophenyl) carbonate, now readily available from bis(trichloromethyl) carbonate, proved a very useful selective reagent.The bicyclic isomer formed from an N1-substituted compound by intramolecular addition was also studied and afforded novel products from 2,4,5-trichlorophenyl N-(2-chloroethyl)-N-nitrosocarbamate, a standard reagent for producing N-nitrosoureas.

1-Aziridine carboxylic acid derivatives with immunostimulant activity

2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula STR1 wherein X is a carbamoyl or alkoxycarbonyl radical, and R1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R1 is as above, except for ethyl, are also new.