1346643-50-2

Upstream product

• 2251-50-5 pentafluorobenzoylchloride 
• 1346772-11-9 (Z)-N'-hydroxy-3-methyl-N-propylbenzimidamide 
• 52707-50-3 3-methylbenzaldehyde oxime 
• 61946-92-7 3-methyl-N-hydroxy-benzenecarboximidoyl chloride 
• 620-23-5 m-tolyl aldehyde 

Relevant academic research and scientific papers

Unexpected C-C bond cleavage: Synthesis of 1,2,4-oxadiazol-5-ones from amidoximes with pentafluorophenyl or trifluoromethyl anion acting as leaving group

An unexpected C-C bond cleavage has been observed on pentafluorobenzoylamidoximes under mild basic conditions. This observation has been exploited to develop a new synthesis of 1,2,4-oxadiazol-5-ones from amidoximes using pentafluorobenzoyl chloride or trifluoroacetic anhydride (TFAA) as a double acylating agent. The pentafluorophenyl anion and the trifluoromethyl anion acted as leaving groups in this transformation.