1346772-11-9

Upstream product

• 620-23-5 m-tolyl aldehyde 
• 52707-50-3 3-methylbenzaldehyde oxime 
• 107-10-8 propylamine 
• 61946-92-7 3-methyl-N-hydroxy-benzenecarboximidoyl chloride 

Downstream Products

• 1346643-50-2 4-propyl-3-m-tolyl-1,2,4-oxadiazol-5(4H)-one 

Relevant academic research and scientific papers

Unexpected C-C bond cleavage: Synthesis of 1,2,4-oxadiazol-5-ones from amidoximes with pentafluorophenyl or trifluoromethyl anion acting as leaving group

An unexpected C-C bond cleavage has been observed on pentafluorobenzoylamidoximes under mild basic conditions. This observation has been exploited to develop a new synthesis of 1,2,4-oxadiazol-5-ones from amidoximes using pentafluorobenzoyl chloride or trifluoroacetic anhydride (TFAA) as a double acylating agent. The pentafluorophenyl anion and the trifluoromethyl anion acted as leaving groups in this transformation.