1346681-71-7

Basic information

• Product Name: (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one
• Synonyms: (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one
• CAS NO: 1346681-71-7
• Molecular Weight: 232.323
• Mol File: 1346681-71-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 75-77°C
• CAS DataBase Reference: (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one(1346681-71-7)
• EPA Substance Registry System: (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one(1346681-71-7)

Safety Data

• Hazardous Substances Data: 1346681-71-7(Hazardous Substances Data)

Usage

Description

(1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one is an organic compound with a unique structure that features a hydroxyl group, a mesityl group, and a methyl group. It is characterized by its molecular formula and the arrangement of its atoms, which contribute to its specific properties and potential applications.

Uses

Used in Chemical Synthesis:
(1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for selective functionalization and modification, making it a valuable building block in the development of new molecules with specific properties and applications.
Used in Pharmaceutical Industry:
(1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one is used as a chiral auxiliary in the kinetic resolution of cyclic amines through acylation. This process can be controlled using either the (R,S)or (S,R)-Bode Kinetic Resolution Catalyst, which are commercially available. The compound plays a crucial role in the production of enantiomerically pure compounds, which are essential in the pharmaceutical industry for the development of drugs with improved efficacy and reduced side effects.
Used in Catalyst Development:
The compound's unique structure and reactivity make it a potential candidate for the development of new catalysts. These catalysts can be used in various chemical reactions to improve reaction rates, selectivity, and overall efficiency, leading to more sustainable and cost-effective processes in the chemical and pharmaceutical industries.

Upstream product

• 487-68-3 mesytaldehyde 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 

Downstream Products

• 1346682-01-6 benzyl (2R)-2-methylazepane-1-carboxylate 
• 1346682-02-7 (2S)-1-(3-mesitylpropanoyl)-2-methylazepane 
• 1346681-94-4 benzyl (3R)-3-methylmorpholine-4-carboxylate 
• 1346681-95-5 (3S)-4-(3-mesitylpropanoyl)-3-methyl morpholine 
• 481038-59-9 (3R)-3-benzylmorpholine 
• 1346681-96-6 (3S)-3-benzyl-4-(3-mesitylpropanoyl)morpholine 
• 77897-23-5 (3S)-3-benzylmorpholine 
• 1346681-74-0 (S)-1-(3-mesitylpropanoyl)-2-methyl piperidine 
• 1346681-86-4 (2R)-2-(3-fluorobenzyl)-1-(3-mesitylpropanoyl)piperidine 
• 1346682-03-8 (4aR,9aS)-4-[(3-mesitylpropanoyl)oxy]-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one 
• 1346681-82-0 (2R)-2-benzyl-1-(3-mesitylpropanoyl)piperidine 

Relevant articles and documents

KINETIC RESOLUTION OF CHIRAL AMINES

The present invention refers to a method for the kinetic resolution of a chiral primary or secondary amine by treating the amine with a chiral, hydroxamic acid derived reagent of the formula (I). These chiral reagents are particularly useful for the kinetic resolution of cyclic amines and may be generated in situ in the presence of an N-heterocyclic carbene, thus allowing for a catalytic reaction.