481038-59-9

Basic information

• Product Name: (R)-3-BENZYLMORPHOLINE
• Synonyms: (R)-3-BENZYLMORPHOLINE;(R)-3-(Phenylmethyl)morpholine;(R)-3-BenzylMorpholine HCl;(3R)-3-(phenylmethyl)-Morpholine
• CAS NO: 481038-59-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 481038-59-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 280℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.031
• Vapor Pressure: 0.00388mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-3-BENZYLMORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-BENZYLMORPHOLINE(481038-59-9)
• EPA Substance Registry System: (R)-3-BENZYLMORPHOLINE(481038-59-9)

Safety Data

• Hazardous Substances Data: 481038-59-9(Hazardous Substances Data)

Usage

General Description

"(R)-3-Benzylmorpholine" is a chemical compound with the molecular formula C11H15NO. It is an enantiomer of 3-benzylmorpholine, a heterocyclic amine compound. This chemical is used in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block in organic synthesis and drug discovery. Additionally, it has potential applications in the field of medicinal chemistry and may exhibit biological activity that could be beneficial for therapeutic purposes. Overall, (R)-3-Benzylmorpholine is a versatile and important chemical compound with various potential uses in the pharmaceutical and agricultural industries.

InChI:InChI=1/C11H15NO/c1-2-4-10(5-3-1)8-11-9-13-7-6-12-11/h1-5,11-12H,6-9H2/t11-/m1/s1

Upstream product

• 7684-27-7 3-benzylmorpholine 
• 1643771-09-8 (S)-2-oxo-3,4-dihydroquinolin-1(2H)-yl 2-methoxy-2-phenylacetate 
• 1643771-12-3 (S)-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-2-phenylacetate 
• 1643770-98-2 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-ethyl-2-phenylacetate 
• 1643770-99-3 (R)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-fluoro-3-(4-methoxyphenyl)propanoate 
• 1643771-00-9 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-3-phenylpropanoate 
• 1643771-01-0 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-azido-3-phenylpropanoate 
• 1643771-04-3 (4aR,9aS)-6-bromo-3-oxo-2,3,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-4(4aH)-yl 2-phenylacetate 
• 1643771-02-1 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate 
• 1643771-03-2 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate 
• 1643770-97-1 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-2-phenylacetate 
• 1643771-08-7 (2S)-(4aR,9aS)-6-bromo-3-oxo-2,3,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-4(4aH)-yl 2-methoxy-2-phenylacetate 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1052208-80-6 C₂₀H₂₄N₂O₂S 
• 1643770-63-1 (2R)-1-((3R)-3-benzylmorpholino)-2-methoxy-2-phenylethanone 
• 1643770-71-1 C₂₁H₂₄FNO₃ 
• 1643770-70-0 (2S)-1-((3R)-3-benzylmorpholino)-2-phenylbutan-1-one 
• 1643770-72-2 (2S)-1-((3R)-3-benzylmorpholino)-2-methoxy-3-phenylpropan-1-one 
• 1643770-73-3 (2S)-2-azido-1-((3R)-3-benzylmorpholino)-3-phenylpropan-1-one 
• 1643770-74-4 benzyl ((2S)-1-((3R)-3-benzylmorpholino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1643770-75-5 2-((2S)-1-((3R)-3-benzylmorpholino)-1-oxo-3-phenylpropan-2-yl)isoindoline-1,3-dione 

Relevant articles and documents

Using the competing enantioselective conversion method to assign the absolute configuration of cyclic amines with BODE’s acylation reagents

The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.

Stereoelectronic basis for the kinetic resolution of n-heterocycles with chiral acylating reagents

The kinetic resolution of N-heterocycles with chiral acylating agents reveals a previously unrecognized stereoelectronic effect in amine acylation. Combined with a new achiral hydroxamate, this effect makes possible the resolution of various N-heterocycles by using easily prepared reagents. A transition-state model to rationalize the stereochemical outcome of this kinetic resolution is also proposed.

Catalytic asymmetric synthesis of substituted morpholines and piperazines

Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3-substituted morpholines and the diastereoselective synthesis of 2,5-substituted piperazines. Copyright