1346682-36-7

Basic information

• Product Name: 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one
• Synonyms: 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one
• CAS NO: 1346682-36-7
• Molecular Weight: 316.759
• Mol File: 1346682-36-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one(1346682-36-7)
• EPA Substance Registry System: 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one(1346682-36-7)

Safety Data

• Hazardous Substances Data: 1346682-36-7(Hazardous Substances Data)

Upstream product

• 124980-95-6 (E)-3-(4-fluorophenyl)-2-propen-1-ol 
• 121133-16-2 rac-(3-(4-fluorophenyl)oxiran-2-yl)methanol 
• 1346682-17-4 2-(4-fluorophenyl)-3-((prop-2-ynyloxy)methyl)oxirane 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1346682-24-3 1-(4-fluorophenyl)-3-(prop-2-ynyloxy)propan-2-one 

Downstream Products

• 1346682-67-4 4-(4-chlorophenyl)-6-fluoro-1,3-dihydronaphtho[2,3-c]furan 

Relevant articles and documents

Synthesis of arylnaphthalene lignan scaffold by gold-catalyzed intramolecular sequential electrophilic addition and benzannulation

An intramolecular approach to generate compounds containing an arylnaphthalene lignan scaffold in high yields is presented. It involves a sequential intramolecular electrophilic attack of carbonyl on arylalkyne followed by benzannulation catalyzed by gold salt. AuCl3 in combination with AgSbF6 works better to effect this transformation. Selected products have been converted into arylnaphthalene lactone natural products such as justicidin E, taiwanin C, and retrojusticidin B (Figure presented).