1346752-20-2Relevant academic research and scientific papers
N-heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals
Zhang, Yuexia,Du, Yu,Huang, Zhijian,Xu, Jianfeng,Wu, Xingxing,Wang, Yuhuang,Wang, Ming,Yang, Song,Webster, Richard D.,Chi, Yonggui Robin
supporting information, p. 2416 - 2419 (2015/03/04)
An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
