134677-28-4

Usage

Uses

Used in Fragrance Industry:
(S)-1-(3-Methoxyphenyl)propanol is used as a fragrance ingredient for its floral, herbal scent and its ability to act as a fixative in perfumes and personal care products, enhancing the longevity of the scent.
Used in Flavor Industry:
In the food industry, (S)-1-(3-Methoxyphenyl)propanol is used as a flavoring agent, contributing to the unique taste profiles of various products.
Used in Pharmaceutical Synthesis:
(S)-1-(3-Methoxyphenyl)propanol is used as a key intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new medications.
Used in Agrochemical Synthesis:
Similarly, PMPP is utilized in the synthesis of agrochemicals, where it serves as an important component in the creation of various agricultural products.
Regulation and Safety:
(S)-1-(3-Methoxyphenyl)propanol is considered safe for use in cosmetic products and is regulated by various authorities to ensure its safety for human health and the environment. This highlights the importance of responsible use and handling of PMPP in all its applications.

Upstream product

• 557-20-0 diethylzinc 
• 591-31-1 3-methoxy-benzaldehyde 
• 2386-64-3 ethylmagnesium chloride 
• 6971-51-3 3-methoxybenzyl alcohol 
• 68266-31-9 1-chloro-1-(3-methoxyphenyl)propane 
• 58824-50-3 1-(3-methoxyphenyl)-2-propen-1-ol 
• 925-90-6 ethylmagnesium bromide 
• 97-93-8 triethylaluminum 

Downstream Products

• 214477-03-9 C₂₀H₂₆O₄Se₂ 

Relevant academic research and scientific papers

Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide

(Figure Presented) A strong asymmetric amplification is observed in the addition of diethylzinc on aromatic aldehydes in the presence of the bistriflamide of trans-1,2-diaminocyclohexane 3a. The asymmetric amplification originates from the insolubility of

Asymmetric amplification by kinetic resolution using a racemic reagent: Example in amine acetylation

The reaction of a racemic reagent on a mixture of enantiomers with small ee (ee = enantiomeric excess) has been studied for amine acylation. A substantial asymmetric amplification could be- realized, for example, from 67 to > 95.5 ee. The combination of asymmetric amplifications is subsequently discussed. Two sequential asymmetric amplifications, one using a racemic reagent and another using a positive nonlinear effect allowed us to start from 1.5 % ee and end with a large amount of a product of 97% ee.

Solvent-free direct aza-Friedel-Crafts reactions between 3,4-dihydroisoquinoline and 1- or 2-naphthols

A self-catalytic aza-Friedel-Crafts method was employed to generate 1-naphtholyl tetrahydroisoquinoline products under neat conditions. In addition, a derivative was prepared in its enantiomerically pure form and has shown moderate activity for asymmetric catalysis in the asymmetric diethylzinc addition to aldehydes.

Enantioselective addition of diethylzinc to aldehydes using immobilized chiral BINOL-Ti complex on ordered mesoporous silicas

A chiral (S)-BINOL ligand has been covalently grafted on ordered mesoporous silicas-MCM-41 and SBA-15 and the resulting inorganic-organic hybrid materials used as chiral auxiliaries in Ti-promoted enantioselective addition of diethyl zinc to aldehydes und

Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols

Taking advantage of the opposite chirality of two privileged starting materials, l-cysteine and d-penicillamine, a wide range of thiazolidine-based amino alcohols was synthesized. l-Cysteine derivatives were more efficient chiral inductors than the d-peni

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.

Linear β-amino alcohol catalyst anchored on functionalized magnetite nanoparticles for enantioselective addition of dialkylzinc to aromatic aldehydes

A linear β-amino alcohol ligand, previously found to be a very efficient catalyst for enantioselective addition of dialkylzinc to aromatic aldehydes, has been anchored on differently functionalized superparamagnetic core-shell magnetite-silica nanoparticles (1a and 1b). Its catalytic activity in the addition of dialkylzinc to aldehydes has been evaluated, leading to promising results, especially in the case of 1b for which the recovery by simple magnetic decantation and reuse was successfully verified. This journal is

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Novel Thiophene-Based Chiral Ligands

Abstract: Chiral norephedrine-derived β-amino alcohols with a thiophene moiety were synthesized from thiophene carbaldehydes (methyl- or ethyl-substituted) and chiral amino alcohols, such as both enantiomers of norephedrine and 2-aminopropanol. The synthesized ligands were applied to the catalytic asymmetric addition of diethylzinc to aldehydes to obtain optically active alcohols with a high conversion (92%) and excellent enantioselectivities (ee up to 99%). The highest enantioselectivity (ee 99%) was obtained with p-trifluorobenzaldehyde as the substrate containing the strongly electron-acceptor CF3 group.

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands

Abstract: Chiral oxazoline ligands containing an aromatic ring were prepared fromnorephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. Thesynthesized ligands were used in the copper-catalyzed asymmetric addition ofdiethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-olswith high conversion (92%) and enantioselectivity (up to 99% ee).

New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes

A study aimed at the synthesis and structure optimization of new, efficient, optically active β-amino alcohol ligands with a structure suitable for immobilization on magnetite nanoparticles has been carried out. The optimized homogeneous amino alcohol catalysts 13a and 13b, the chirality of which arises from the Sharpless epoxidation of suitable allyl alcohols, were tested by employing the well-established enantioselective amino alcohol-promoted addition of diethylzinc to benzaldehyde, giving the corresponding benzyl alcohol with nearly quantitative yield and ee = 95%. Then, their broad applicability as chiral catalysts was evaluated by carrying out the same reaction on a family of aldehydes, including variously substituted aromatic ones as well as an aliphatic analogue. The results have confirmed the validity of the fine-tuning process performed on ligands 13a and 13b. In fact, both exhibited excellent catalytic activity as demonstrated by the chemical yields and ee obtained from all the tested aldehydes, almost independent of the position and type of substitution in the aromatic ring.