1346789-52-3Relevant academic research and scientific papers
Regioselective Rh-catalyzed direct carbonylation of indoles to synthesize indole-3-carboxylates
Lang, Rui,Wu, Junliang,Shi, Lijun,Xia, Chungu,Li, Fuwei
supporting information; experimental part, p. 12553 - 12555 (2012/02/02)
Rh-catalyzed C-H carbonylation of indoles under 1 atm of CO has been achieved. Various substituted indoles and indole with free N-H could be carboxylated with linear- and/or cyclic-alcohol to give the desired indole-3-carboxylates with up to 92% yield. A mechanism involving Rh III initiated C-H metallation is proposed.
