1346939-72-7

Basic information

• Product Name: (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone
• Synonyms: (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone
• CAS NO: 1346939-72-7
• Molecular Weight: 433.593
• Mol File: 1346939-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone(1346939-72-7)
• EPA Substance Registry System: (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone(1346939-72-7)

Safety Data

• Hazardous Substances Data: 1346939-72-7(Hazardous Substances Data)

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 2069-48-9 4-chloro-4'-fluoro-benzophenone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1188303-84-5 2-(4-butylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 1346939-70-5 (4'-(dimethylamino)biphenyl-4-yl)(4-fluorophenyl)methanone 

Relevant articles and documents

Nickel-catalyzed Suzuki-Miyaura reaction of aryl fluorides

Two protocols for the nickel-catalyzed cross-coupling of aryl fluorides with aryl boronic esters have been developed. The first employs metal fluoride cocatalysts, such as ZrF4 and TiF4, which enable Suzuki-Miyaura reactions of aryl fluorides bearing electron-withdrawing (ketones, esters, and CF3), aryl and alkenyl groups as well as those comprising fused aromatic rings, such as fluoronaphthalenes and fluoroquinolines. The second protocol employs aryl fluorides bearing ortho-directing groups, which facilitate the difficult C-F bond activation process via cyclometalation. N-heterocycles, such as pyridines, quinolines, pyrazoles, and oxazolines, can successfully promote cross-coupling with an array of organoboronic esters. A study into the substituent effects with respect to both coupling components has provided fundamental insights into the mechanism of the nickel-catalyzed cross-coupling of aryl fluorides.