134699-79-9Relevant academic research and scientific papers
Variations in site of lithiation of N-[2-(4-methoxyphenyl)ethyl]pivalamide - Use in ring substitution
Alshammari, Mohammed B.,El-Hiti, Gamal A.,Smith, Keith
, p. 117 - 119,3 (2013/02/23)
Lithiation of N-[2-(4-methoxyphenyl)ethyl]pivalamide at -20 to 0 °C with three equivalents of n-BuLi in anhydrous THF, followed by reactions with various electrophiles, gives high yields of products involving ring substitution ortho to the pivaloylaminoet
3-Amino-2-arylpropanoic acids by electrophilic substitution of 2-arylethylamines at the benzylic position
Simig,Schlosser
, p. 1963 - 1964 (2007/10/02)
A reaction sequence consisting of N-pivaloylation, lithiation at the benzylic position, carboxylation and deprotection allows to convert 2-arylethylamines into 3-amino-2-arylpropanoic acids with good yields.
