134700-29-1Relevant articles and documents
The synthesis and antituberculosis activity of 5-alkynyl uracil derivatives
Platonova, Yana B.,Tomilova, Larisa G.,Volov, Alexander N.
supporting information, (2020/06/26)
A series of new 5-alkynyl-substituted uracil and uridine derivatives were synthesised via palladium-catalysed Sonogashira cross-coupling reaction of 5-bromo-pyrimidine base with terminal acetylenes with good yields in DMF at room temperature. All obtained compounds were tested for antimycobacterial activity against Mycobacetrium bovis and Mycobacterium tuberculosis (H37Ra) at concentrations of 1–100 μg/ml using MABA test. Obtained results revealed that most of tested uracil derivatives exhibited high antimycobacterial activity (MIC50 = 1.1–19.2 μg/ml) in comparison with therapeutic agents such as rifampicin, isoniazid and D-cycloserine, excluding compounds having alkyl substituent at triple alkyne bond.
PNA-DNA chimeras containing 5-alkynyl-pyrimidine PNA units. Synthesis, binding properties, and enzymatic stability
Bajor, Zoltan,Sagi, Gyula,Tegyey, Zsuzsanna,Kraicsovits, Ferenc
, p. 1963 - 1983 (2007/10/03)
Three chimeric dimer synthons (oeg_tNHT, oeg_upNHT and oeg_uhNHT) containing thymine (t), 5-(1-propynyl)-uracil (up) and 5-(1-hexyn-1-y1)-uracil (uh) PNA units with N-(2-hydroxyethyl)glycine (oeg) backbone were synthesized
Antiviral pyrimidine nucleosides
-
, (2008/06/13)
Pyrimidine 4'-thionucleosides of the formula I STR1 wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C2-6 alkyl, C2-6 alkenyl, C2-6 haloalkenyl or C2-6 alkynyl and physiologically functional derivatives thereof. These compounds have utility as anti-vital agents.