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Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Dichloro-2-methoxypyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various medicinal compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-Dichloro-2-methoxypyridine is utilized as an intermediate in the production of insecticides and herbicides, playing a crucial role in the formulation of effective pest control agents that protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
3,5-Dichloro-2-methoxypyridine is employed as a building block in the synthesis of other organic compounds, showcasing its versatility in organic chemistry and its potential to contribute to the creation of specialty chemicals for diverse applications.

Upstream product

• 16063-70-0 2,3,5-trichloropyridine 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties

In this work on the design and studies of luciferins related to the blue-hued coelenterazine, the synthesis of heterocyclic analogues susceptible to produce a photon, possibly at a different wavelength, is undertaken. Here, the synthesis of O-acetylated derivatives of imidazo[1,2-b]pyridazin-3(5 H)-one, imidazo[2,1-f][1,2,4]triazin-7(1 H)-one, imidazo[1,2-a]pyridin-3-ol, imidazo[1,2-a]quinoxalin-1(5 H)-one, benzo[f]imidazo[1,2-a]quinoxalin-3(11 H)-one, imidazo[1′,2′:1,6]pyrazino[2,3-c]quinolin-3(11 H)-one, and 5,11-dihydro-3 H-chromeno[4,3-e]imidazo[1,2-a]pyrazin-3-one is described thanks to extensive use of the Buchwald–Hartwig N-arylation reaction. The acidic hydrolysis of these derivatives then gave solutions of the corresponding luciferin analogues, which were studied. Not too unexpectedly, even if these were “dressed” with substituents found in actual substrates of the nanoKAZ/NanoLuc luciferase, no bioluminescence was observed with these compounds. However, in a phosphate buffer, all produced a light signal, by chemiluminescence, with extensive variations in their respective intensity and this could be increased by adding a quaternary ammonium salt in the buffer. This aspect was actually instrumental to determine the emission spectra of many of these luciferin analogues.