134742-26-0

Basic information

• Product Name: 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chloro-phenyl]carbamoyl]ben zamide
• Synonyms: 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chloro-phenyl]carbamoyl]ben zamide
• CAS NO: 134742-26-0
• Molecular Formula: C₁₈H₁₃BrClN₅O₃
• Molecular Weight: 462.68
• Mol File: 134742-26-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.663g/cm³
• Refractive Index: 1.708
• CAS DataBase Reference: 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chloro-phenyl]carbamoyl]ben zamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chloro-phenyl]carbamoyl]ben zamide(134742-26-0)
• EPA Substance Registry System: 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chloro-phenyl]carbamoyl]ben zamide(134742-26-0)

Safety Data

• Hazardous Substances Data: 134742-26-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H13BrClN5O3/c19-10-8-22-18(23-9-10)28-15-6-5-11(7-13(15)20)24-17(27)25-16(26)12-3-1-2-4-14(12)21/h1-9H,21H2,(H2,24,25,26,27)

Upstream product

• 105128-93-6 N-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N'-(2-nitrobenzoyl)-urea 

Downstream Products

• 150096-82-5 ({[(2-{3-[4-(5-bromo-pyrimidin-2-yloxy)-3-chloro-phenyl]-ureidocarbonyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester 
• 150096-73-4 N-<4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl>-N'-(2-tert-butoxycarbonyl-glycylamino)benzoylurea 

Relevant articles and documents

Synthesis and antitumor activities of water-soluble benzoylphenylureas

Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.