1347574-22-4Relevant academic research and scientific papers
Synthesis and anti-cancer activities of glycosides and glycoconjugates of diterpenoid isosteviol
Sharipova, Radmila R.,Belenok, Mayya G.,Garifullin, Bulat F.,Sapunova, Anastasiya S.,Voloshina, Alexandra D.,Andreeva, Olga V.,Strobykina, Irina Yu.,Skvortsova, Polina V.,Zuev, Yuriy F.,Kataev, Vladimir E.
, p. 1488 - 1498 (2019/08/20)
A series of glycosides and glycoconjugates of diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) with various monosaccharide residues were synthesized and their cytotoxicity against some human cancer and normal cell lines was assayed. Most of the synthesized compounds demonstrated moderate to significant cytotoxicity against human cancer cell lines M-HeLa and MCF-7. Three lead compounds exhibited selective cytotoxic activities against M-HeLa (IC50 = 10.0-15.1 μM) that were three times better than the cytotoxicity of the anti-cancer drug Tamoxifen (IC50 = 28.0 μM). Moreover, the lead compounds were not cytotoxic with respect to the normal human cell line Chang liver (IC50 > 100 μM), whereas Tamoxifen inhibited the viability of normal human Chang liver cells with an IC50 value of 46.0 μM. It was determined that the cytotoxicity of the lead compounds was due to induction of apoptosis proceeding along the mitochondrial pathway. The cytotoxic activity of the synthesized compounds substantially depended on the nature of the monosaccharide residue and its position, that is, whether the monosaccharide residue was attached directly to the isosteviol skeleton or was moved away from it by means of a polymethylene linker.
REBAUDIOSIDE A DERIVATIVE PRODUCTS AND METHODS FOR MAKING
-
Page/Page column 35-38, (2009/10/21)
Exemplary embodiments of this invention encompass a method for degrading rebaudioside A and the rebaudioside A derivative products derived therefrom. In particular, this invention relates to a method for degrading rebaudioside A compositions to obtain rebaudioside A derivative products suitable for use as sweetener compositions.
