13476-32-9

Basic information

• Product Name: 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-
• Synonyms: 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-
• CAS NO: 13476-32-9
• Molecular Formula: C20H28 O2
• Molecular Weight: 300.44
• Mol File: 13476-32-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(13476-32-9)
• EPA Substance Registry System: 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(13476-32-9)

Safety Data

• Hazardous Substances Data: 13476-32-9(Hazardous Substances Data)

Upstream product

• 20055-63-4 7-Oxo-5,10-seco-totara-5,8,10⁽²⁰⁾,11,13-pentaen-13-ol 
• 19912-95-9 6α-bromo-13-hydroxytotara-8,11,13-trien-7-one 
• 907-06-2 13-acetoxy-6α-bromototara-8,11,13-trien-7-one 
• 19913-00-9 7-Oxo-5.10-seco-totara-8.10⁽²⁰⁾.11.13-tetraen-13-ol 
• 1048-23-3 13-acetoxytotara-8,11,13-trien-7-one 
• 15340-82-6 13-acetoxytotara-8,11,13-triene 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B

Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.