19912-95-9

Basic information

• Product Name: 9(1H)-Phenanthrenone, 10-bromo-2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10R,10aS)-
• Synonyms: 9(1H)-Phenanthrenone, 10-bromo-2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10R,10aS)-
• CAS NO: 19912-95-9
• Molecular Formula: C20H27 Br O2
• Molecular Weight: 379.33
• Mol File: 19912-95-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9(1H)-Phenanthrenone, 10-bromo-2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10R,10aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9(1H)-Phenanthrenone, 10-bromo-2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10R,10aS)-(19912-95-9)
• EPA Substance Registry System: 9(1H)-Phenanthrenone, 10-bromo-2,3,4,4a,10,10a-hexahydro-7-hydroxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10R,10aS)-(19912-95-9)

Safety Data

• Hazardous Substances Data: 19912-95-9(Hazardous Substances Data)

Upstream product

• 907-06-2 13-acetoxy-6α-bromototara-8,11,13-trien-7-one 
• 1048-23-3 13-acetoxytotara-8,11,13-trien-7-one 
• 15340-82-6 13-acetoxytotara-8,11,13-triene 

Downstream Products

• 13476-32-9 7-oxototarol 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B

Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.